In April 2023, a joint safety alert was issued by the British Menopause Society, the Faculty of Sexual and Reproductive Health, the Royal College of General Practitioners, and the Royal College of Obstetricians and Gynaecologists. This alert highlighted concerns about an increasing number of women being prescribed high doses of oestrogen that exceed licensed product limits.
Oestrogen should not be routinely prescribed at doses higher than those established and tested in clinical research. The upper recommended limits are:
- Estradiol 0.06% gel:Maximum of 4 pumps
- Estradiol patch:Maximum of 100 mcg
- Oral Estradiol tablets:Maximum of 2 mg
We are aware that some private providers may prescribe oestrogen above these recommended limits. However, our practice policy is that we cannot prescribe any medication that would contribute, even in part, to an overall treatment dose exceeding these limits, as this would constitute prescribing beyond established safety guidelines. This decision was made with careful consideration, as prolonged use of excessive oestrogen doses may pose significant health risks.
Therefore, if you are receiving oestrogen above the recommended limits, we request that you obtain your full medication supply privately. Alternatively, you may choose to reduce your prescribed oestrogen dose. If you feel unable to lower your dose and are unable to fund private treatment, please speak with us about the possibility of referral to an NHS complex menopause clinic for further management.
If you believe you may be taking a dose higher than the recommended limits or a combination of different oestrogen products (excluding vaginal oestrogen cream 0.1% or pessary 10 mcg), we strongly advise booking an appointment with our clinical pharmacist. This will allow us to review any potential risks and ensure your HRT regimen is safe.
Excessive oestrogen intake may increase the risk of uterine (womb) cancer, as well as potentially raising the risk of breast or ovarian cancer.
For further details, please refer to the British Menopause Society news update. The full technical statement can be accessed via the following link:
https://thebms.org.uk/2023/04/joint-bms-fsrh-rcgp-rcog-sfe-and-rcn-womens-health-forum-safety-alert/
Updated:15.04.25